Histomorphometry

Histomorphometry is the quantitative study of the microscopic organization and structure of a tissue, such as bone. The term especially applies to a study conducted by computer-assisted analysis of images acquired from a microscope. Histomorphometric studies are of special importance in determining changes that take place in the bones or teeth following bone grafting and implant procedures. The microscopic images allow for a detailed analysis of changes to the surface of the tissue, implant, or prosthesis as well as changes in their underlying structures. The information gained from such analyses can then be used to create more reliable and longer-lasting implants, to determine which type of microtexture is more successful for bone-to-bone contact, and how texture of the implant surface affects the osteoconductive capacity. Though implants and prostheses can be evaluated on a larger mechanical level, the use of histomorphometry provides insight into what is happening on the microscopic and cellular levels.