Leukocyte and Platelet Rich Fibrin (L-PRF)

Leukocyte and platelet rich fibrin (L-PRF) is a second-generation autologous chairside preparation of platelet concentrate derived from whole venous blood. It is obtained through a specific process of gradient density centrifugation that limits the degree of blood manipulation without requiring the use of a platelet activator. L-PRF produces a dense fibrin matrix that incorporates leukocytes, platelets, and high concentrations of growth factors. When compressed, the resulting fibrin matrix is strong, pliable, and can be sutured for use as a stand-alone product to improve wound healing and promote tissue regeneration. The matrix can also be incorporated into particulate bone graft materials or other biomaterials to improve both the handling characteristics and the healing properties of the particulate material. The use of leukocyte and platelet rich fibrin immediately following a procedure can reduce the swelling and discomfort experienced by the patient while also speeding the regeneration, wound healing, and recovery processes.


Levofloxacin (brand name, Levaquin) is a type of fluoroquinolone antibiotic with a broad spectrum of action. It may be used either orally or parenterally. In implant dentistry it is most often used for severe infections, especially in the maxillary sinus. Levofloxacin is effective in the treatment of bacterial infections that are caused by several different types of bacteria including Escherichia coli, Campylobacter jejuni, Yersenia pestis, and Bacillus anthracis among others. This antibiotic is an effective choice against bacteria as it prevents the reproduction or repair of their genetic material. This prevents bacteria from undergoing binary fission and reproducing new bacterium. Levofloxacin is a powerful antibiotic and therefore comes with possible side effects. Among the most common are nausea, vomiting, diarrhea, and constipation. However, more serious side effects such as tendonitis, tendon rupture, and muscle weakness are also possible. The dosage of levofloxacin will depend upon the age and weight of the patient as well as the type of bacteria being targeted.