Glucocorticoids, or corticosteroids, are a class of steroid hormones that are characterized by an ability to bind with the glucocorticoid receptor. In dentistry, their main therapeutic use is as an anti-inflammatory agent and immunosuppressant. Some of the more commonly used glucocorticoids include betamethasone, dexamethasone, methylprednisolone, prednisolone, prednisone, and triamcinolone. Glucocorticoids can be used for or following a variety of dental procedures such as endodontics for root resorption, oral surgeries to reduce edema and to aid in the prevention of ulcerations and excoriation, and the treatment of oral submucosa fibrosis and oral lichen planus. The use of glucocorticoids can reduce patient discomfort, lessen the time required for healing, aid in the healing process, and aid in the prevention of post-operative issues. The type of steroid used will depend upon the patient’s medical history, prior use of glucocorticoids, type of dental procedure, and the symptom or symptoms that need relieving.